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Patents & Publications

Patents & Publications

Our technology is backed by two European patents and recognized in numerous scientific publications.

Patents

Transducer:
(WO2010/026269) – The transducers are based on the BICELL (Bio-Photonic Sensing Cells) concept developed by our research group. The BICELLs are networks of optical interferometers that change their response in reaction to the immobilization of biomolecules.

Readout Platform:
(WO2014/020159) – In order to improve the detection limit not only the sensitivity of the transducers themselves, but also the uncertainty in the interrogation process is of crucial importance. Thanks to this invention with which we introduced a new measurement variable called IROP (Increased Relative Optical Power), we are able to improve the detection limit by the order of one magnitude for the same transducer.

Assay method:
(Published as ES2750374A1) – Optical detection method that allows qualitative and /or quantitative analysis of a target molecule in a complex matrix biological sample, improving the detection limit by amplification in the signal.

patents

Publications

(most relevant)

R.L. Espinosa, M.F. Laguna, F. Fernández, B. Santamaría, F.J. Sanza,  M.V. Maigler, J.J. Álvarez-Millán, V. Canalejas-Tejero, M. Holgado.

Sensors, 18(8) (2018)

M.V. Maigler, M. Holgado, M.F. Laguna, F.J. Sanza, B. Santamaría, A. Lavín, R.L. Espinosa.
IEEE Transactions on Instrumentation and Measurement (2019)

A. Lavín, J. de Vicente, M. Holgado, M.F. Laguna, R. Casquel, B. Santamaría, M.V. Maigler, A.L. Hernández, Y. Ramírez.

Sensors, 18(7) (2018)

V. Canalejas-Tejero, Ana L. Hernández, R. Casquel, Sergio A. Quintero, María F. Laguna, M. Holgado.

Optical Material Express, 8 (2018)

A. L. Hernández,  R. Casquel, M. Holgado, I. Cornago, F. Fernández, P. Ciaurriz, F.J. Sanza, B. Santamaría, M. V. Maigler, S. Quintero, M.F. Laguna.

Sensors and Actuators B, 259 (2018)

F. Fernández, P. Ciaurriz, I. Cornago, R. Casquel, A.L. Hernández, F.J. Sanza, M.F. Laguna, M. Holgado.

Sensors and Actuators B, 244 (2017)

B. Santamaría, M.F. Laguna, D. López-Romero, A. López, F.J. Sanza, A. Lavín, R. Casquel , M. Maigler, R. Espinoza, M. Holgado.

Sensors, 17 (2017)

A. López, R. Casquel, M. Holgado, I. Cornago, F. Fernández, P. Ciaurriz, F.J. Sanza, B. Santamaría, M. Maigler, M.F. Laguna.

Optics Letters, 41 (2016)

M. Holgado, M.V. Maigler, B. Santamaria, A.L. Hernández, A. Lavín, M.F. Laguna, F.J. Sanza, D. Granados, R. Casquel, J. Portilla, T. Riesgo.

Sensors and Actuators, B 236 (2016)

Ana L. Hernández, R. Casquel, M. Holgado, I. Cornago, F.J. Sanza, B. Santamaría, M. Maigler, F. Fernández, A. Lavín, M.F. Laguna.

Optics Letter, 40 (2015)

M.F. Laguna, M. Holgado, A.L. Hernández, B. Santamaría, A. Lavín, J. Soria, T. Suarez, C. Bardina, M. Jara, F.J. Sanza, R. Casquel.

Sensors, 15 (2015)

M.F. Laguna, F.J. Sanza, J. Soria, M. Jara, A. Lavín, R. Casquel, A.L. Hernández,  T. Suárez, M. Holgado.

Sensors and Actuators B, 203 (2014)

M. Holgado, F.J. Sanza, A.L. Hernández, A. Lavín, R. Casquel, M.F. Laguna.

Sensors, 14 (2014)

M.F. Laguna, M. Holgado, F.J. Sanza, A. Lavín, A.L. Hernández, R. Casquel.

Sensors, 14 (2014)

F.J. Ortega, M.J. Bañuls, F.J. Sanza, M.F. Laguna, M. Holgado, R. Casquel, C.A. Barrios, D. López-Romero, A. Maquieira, R. Puchades.

Journal of Materials Chemistry B, 21 (2013)

A. Lavín, R. Casquel, F.J. Sanza, M.F. Laguna, M. Holgado.

Sensors and Actuators B, 176 (2013)

F.J. Sanza, M. Holgado, F.J. Ortega, R. Casquel, D. López-Romero, M.F. Laguna, M.J. Bañuls, C.A. Barrios, R. Puchades, A. Maquieira.

Biosensors and Bioelectronics, 26 (2011)

F.J. Aparicio, M. Holgado, I. Blaszczyk-Lezak, A. Borras, A. Griol, C.A. Barrios, R. Casquel, F.J. Sanza, H. Sohlström, M. Antelius, A.R. González-Elipe, A. Barranco.

Advanced Materials, 23 (2011)